A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of Ceftazidime (CTZ) and Clavulanic acid (CA) by employing area under curve method in dist.water. The area at 250-260 nm was used for quantification of Ceftazidime and 275-285 nm for quantification of Clavulanic acid. The linearity was established over the concentration range of 4-20 Ã?µg/ml and 50-250 Ã?µg/ml for Ceftazidime and Clavulanic acid with correlation coefficient r2 0.9951 and 0.9956, respectively. The mean % recoveries were found to be in the range of 99.91 % ââ?¬â?? 99.93 % and 99.68 % ââ?¬â?? 100.08 % for Ceftazidime and Clavulanic acid, respectively. The proposed method has been validated as per ICH guideline and successfully applied to the estimation of pharmaceutical dosage form.
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